Marc Hamilton, Professor of Health and Human Performance at the University of Houston, has discovered such an approach for optimal activation – he’s pioneering the “soleus push-up” (SPU) which effectively elevates muscle metabolism for hours, even while sitting. The soleus, one of 600 muscles in the human body, is a posterior leg muscle that runs from just below the knee to the heel. 

The SPU is said to sustain an elevated oxidative metabolism to improve the regulation of blood glucose. Marc Hamilton advises that Guidance on doing SPUs is yet to be released.

More information: 

  https://www.sciencedirect.com/science/article/pii/S2589004222011415#mmc1

  https://stories.uh.edu/2022-soleus-pushup/index.html